Scream 7

In Woodsboro, Stab fan Scott and his girlfriend Madison visit Stu Macher's house after hearing rumors that he might have survived having a television dropped on his head. They are killed by Ghostface, who sets the house on fire.

In Pine Grove, Indiana, Sidney Prescott has built a new life for herself. She is married to police chief Mark Evans, runs a coffeehouse, and raises her children, including her teenage daughter Tatum, named after Sidney's late best friend Tatum Riley. Sidney receives a call from Ghostface, who requests a videocall and reveals himself as an aged and scarred Stu. Stu announces he is going after Tatum and is outside the theater where she is rehearsing. Sidney arrives with the police as Ghostface flees after killing Tatum's friends Hannah and Aaron.

Later that night, Ghostface emerges from Sidney's attic and knocks Mark unconscious. Sidney takes Tatum to a safe room to evade Ghostface and uses the room's alternate exit to leave the house. Ghostface tries to stab Sidney and Tatum through the wall but is eventually fatally run over by Gale Weathers and her assistants Mindy and Chad Meeks-Martin. Once unmasked, Sidney recognizes the killer as Karl Gibbs, a murderer who escaped from a nearby mental institution and bought coffee from her earlier. Sidney visits the institution, where supervisor Marco Davis recognizes Stu as a recently released "John Doe" that had no memory from before he was in Woodsboro and lived in the room next to Karl.

While Sidney agrees to be interviewed by Gale on live television to lure Stu, Tatum meets her boyfriend Ben, her friends Chloe and Lucas, and the Meeks twins at a tavern. Unbeknownst to them, Mark is ambushed and repeatedly stabbed by Ghostface at home. When the interview ends, Stu calls Sidney and warns that he is outside the tavern. Tatum becomes suspicious of Ben when she finds a laptop in his car running a test to deepfake his face into Stu; she knocks him out and runs away. Ghostface injures the Meeks twins and kills Chloe and Lucas before chasing Tatum through the streets. Ben finds her, but Ghostface kills him, and Tatum flees to Sidney's coffeehouse. Following Sidney's call instructions, Tatum retrieves a gun from her office and shoots Ghostface from behind a wall but finds a second Ghostface at the front door.

Stu calls Sidney and reveals Tatum is now being held captive at home. Sidney finds a televised message from Stu, who then proceeds to change his appearance into previous Ghostface killers Nancy Loomis and Roman Bridger, as well as Gale's late ex-husband Dewey Riley, to tell Sidney he is returning to how the original Woodsboro killings started: a person being forced to watch a captive beloved at home. Sidney finds Tatum tied to a chair while Ghostface holds her at knifepoint. Ghostface reveals himself as Marco, who explains he used his previous experience in information technology to create "Stu". He then drags in a wounded Mark as the second Ghostface unmasks to reveal Sidney's neighbor Jessica Bowden. She explains that after reading Sidney's autobiography, she came to the conclusion that Sidney succeeded because she killed those who tormented her, prompting Jessica to murder her abusive husband, as well as her son Lucas, whom she considered very similar to her husband.

When Sidney disappeared from public life and was not present during the New York City killings, Jessica was disappointed and spent time at the mental institution where she met Marco after discovering where Sidney had moved to. Jessica also explains she will turn Tatum into the new Sidney by repeating the traumatic events that turned Sidney into a final girl. Mark cuts Tatum free, and she attacks Jessica as Sidney shoots Marco dead. Jessica flees, and Sidney chases her before they fight, only stopping once Tatum shoots Jessica. When Jessica attacks again, both Sidney and Tatum repeatedly shoot her in the head.

In the aftermath, Mark is taken to the hospital, and Sidney thanks Gale for having her back and tells Tatum about her namesake. With Gale's blessing, Mindy provides an impromptu news report about the night's events.