Scary Movie

While watching Horror Movie, an in-universe spoof of Scary Movie, teenager Tuesday Campbell is attacked by Ghostface. Tuesday's drug addict older half-sister Sara and her boyfriend Jack Kirsch learn that Tuesday is hospitalized, and suspect the attack is similar to the killing spree conducted by original Ghostface Doofy Gilmore in 2000. They visit Sara's estranged mother Cindy Campbell, who has become a paranoid recluse. Cindy refuses to help as she suspects the killer is luring her out, which upsets Sara.

Tuesday's high school friends, Brenda Meeks's children Brad and Dei, Brad's girlfriend Elle, and town sheriff Greg Phillippe's transgender son Jess, also learn about the attack. The group is soon joined by Brenda's stoner brother Shorty. Brenda, now calling herself "Ma", attends church with her husband Ray Wilkins, who claims to have renounced his homosexuality.

Sara and Jack are attacked by Ghostface in the hospital but escape. They visit Doofy, who has reverted back to his mentally disabled persona. Doofy reluctantly agrees to help and the trio go to Brenda's house. Cindy, having a change of heart, also arrives and Brenda starts theorizing what the plot is. They conclude that Ghostface is taking the "rebootquel" approach by bringing back legacy characters while introducing new ones, and thus, all the original characters are now in danger.

As Ghostface murders Greg and Jess, reporter Gail Hailstorm reconnects with former lover Doofy and trades a handjob for information. Ghostface attacks Tuesday again at the hospital, but Sara and Doofy come to her rescue. Ghostface kills Doofy while Sara gets Tuesday out and are saved by Cindy and Brenda. That night, Shorty smokes too much weed and Ghostface hypnotizes him into a KPop Demon Hunters-style animated sequence.

Shorty hosts a livestream where Ghostface murders celebrity guest Kai Cenat. He also infiltrates an experimental procedure Gail undertakes to make her look young again, injecting her with "The Stuff" before killing her alternate self, Tiffany Wilson. Dei is on the way home in a subway, but Ghostface and several passengers, fed up with their wokeness and victim mentality, stab them to death. While Brenda hosts a Halloween costume party, Brad is killed in the garden. Cindy steals a car and breaks into Brenda's house, fighting a wave of Ghostfaces in a John Wick style.

Ghostface reveals herself as Elle, with Jack as her accomplice. They explain that they want to take over the Scary Movie franchise from the legacy characters. Four more Ghostfaces appear and kill them; they reveal themselves as Anthony Anderson and Shaquille O'Neal, accompanied by Shorty and Ray, who planned the ending plot twist all along. Anthony and Shaquille are betrayed and killed by Shorty and Ray, who have a grudge against Anthony, Shaquille, Cindy and Brenda for participating in Scary Movie 3 and Scary Movie 4 without them. Cindy reminds them that the original four Scary Movie characters are now reunited, convincing them to end the killing spree.

Sara and Tuesday are ecstatic to be the new final girls and propose headlining the franchise going forward with the original characters serving as support, but when they start insulting their elders, Cindy, Brenda, Shorty, and Ray tie them up and leave them to burn to death in the house, declaring that no one will take over the Scary Movie franchise from them.