Spider-Man: Brand New Day

Following Dr. Stephen Strange's spell, the world has forgotten that Peter Parker exists. Four years later, Parker has been anonymously protecting New York City as its celebrated hero Spider-Man, but has distanced himself from those he used to know, including his ex-girlfriend Michelle "MJ" Jones-Watson and former best friend Ned Leeds.

Parker intervenes when a tank rampages through the city and breaks into a Department of Damage Control (DODC) building. The driver had been telepathically possessed, and the telepath body hops from person to person to help Mac Gargan, an enhanced criminal Parker previously captured, to escape. Parker makes inquiries with Yelena Belova, who tells him someone has repeatedly attacked the DODC in search of "V-Max". Parker questions DODC director Bill Metzger, who claims ignorance.

Parker has a chance encounter with Ned and MJ, who have moved back to New York after graduating from MIT. Ned and MJ do not recognize him, and MJ has a new boyfriend. Parker returns home in distress, and the next morning wakes up with heightened senses and organic webs coming out of his wrists. He tracks down Gargan, now possessed, as he tries to break back into the DODC. The telepath mocks him, and Parker reacts with uncharacteristic violence, beating Gargan into unconsciousness and seriously injuring a responding police officer.

Hoping to control his new mutations, Parker speaks to Bruce Banner to ask about the inhibitor device that suppresses his alter ego, the Hulk. Based on Banner's advice, Parker fashions his own inhibitor to limit his powers, and he starts work on a second to suppress the telepath's abilities. Before Parker can finish, the telepath finds him at home and, after learning about MJ, possesses her and tricks Parker into revealing his face. Parker concedes defeat after narrowly saving her, though he sees the telepath directly and takes a photo of her with his HUD.

Parker takes MJ to Frank Castle's hideout to keep her safe. With Castle's equipment and MJ's insight, Parker completes both inhibitors, and he discovers that the telepath is named Jean Grey. When Jean attacks the DODC again, this time in person and using a possessed Hulk, Parker subdues her and turns her over to the DODC. Before losing consciousness, Jean mentions someone named Sara. Metzger claims that Sara is a recently deceased colleague Jean learned about while possessing his mind. When Parker returns, MJ confronts him with the letter he wrote for her and Ned explaining the spell that erased their memories. He explains himself and declares his love but MJ apologizes because she does not know him or reciprocate his feelings. She invites him to her apartment, and he spends time bonding with her and Ned.

After hearing MJ describe that she cannot remember anything while being possessed, Parker realizes Metzger lied to him. He contacts Yelena, who learns from redacted DODC files that Sara is Jean's sister, another telepath who was kidnapped by the DODC. The only clue she has is "V-Max", a message she heard telepathically from Sara, but Metzger does not know what it means and begins experimenting on Jean's mind. Jean realizes "V-Max" is the fading text on the label on the air vent above the holding cell, the last thing Sara saw before she died. Enraged, Jean's abilities grow more powerful, and she psionically locks the city around her.

Parker is partially immune to Jean's abilities and enters the DODC to stop her. Jean rebuffs him and possesses a large group of Hand ninjas for him to fight. Initially overwhelmed, he removes his inhibitor and embraces his new mutations, using his organic webs and heightened senses to defeat the Hand. Parker allows Jean to read his mind, where she finds a memory of his aunt May, who accepted his abilities and loved him for himself. Parker offers Jean understanding over her loss and deliberately puts himself between her and Castle when he tries to shoot her from outside, sustaining a near-fatal wound.

Parker wakes up in the hospital with Castle, who explains that Jean kept him alive while in critical condition. Castle apologizes for his actions and helps Parker leave the hospital unnoticed. In the aftermath, a guilt-ridden Jean quietly leaves the city, Metzger disappears, the DODC comes under investigation, and Parker vows he does not need to be alone to be Spider-Man. When he sees Ned again, he introduces himself.

In a post-credits scene, Ned's "Spidey Tracker" app appears to show Spider-Man located somewhere in outer space.